Human placenta-derived stem cells - Recent findings based on the molecular science
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F20%3A00074038" target="_blank" >RIV/65269705:_____/20:00074038 - isvavai.cz</a>
Result on the web
<a href="https://content.sciendo.com/view/journals/acb/8/4/article-p164.xml?tab_body=abstract" target="_blank" >https://content.sciendo.com/view/journals/acb/8/4/article-p164.xml?tab_body=abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/acb-2020-0021" target="_blank" >10.2478/acb-2020-0021</a>
Alternative languages
Result language
angličtina
Original language name
Human placenta-derived stem cells - Recent findings based on the molecular science
Original language description
The human placenta is a complex, multifunctional transient fetomaternal organ. The placenta is composed of the maternal decidua basalis and its fetal part, consisting of the mesenchymal and trophoblast cell lineages. Both the placenta and the amniotic membranes are abundant in readily available placenta-derived mesenchymal stem cells (PD-MSCs). The clinical application of the PD-MSCs opens new perspectives for regenerative medicine and the treatment of various degenerative disorders. Their properties depend on their paracrine activity - the secretion of the anti-inflammatory cytokines and specific exosomes. In contrast to the PD-MSCs, the trophoblast stem cells (TSCs) are much more elusive. They can only be isolated from the blastocyst-stage embryos or the first-trimester placental tissue, making that procedure quite demanding. Also, other cultures require specific, strictly controlled conditions. TSCs may be potentially used as an in vitro model of various placental pathologies, facilitating the elucidation of their mysterious pathogenesis and creating the environment for testing the new drug efficiency. Nonetheless, it is unlikely that they could be ever implemented as a part of novel cellular therapeutic strategies in humans. Running title: Current knowledge on the placental stem cells.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical Journal of Cell Biology
ISSN
2544-3577
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
PL - POLAND
Number of pages
6
Pages from-to
164-169
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85100134581