The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074406" target="_blank" >RIV/65269705:_____/21:00074406 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/21:00078662 RIV/00216224:14110/21:00122136
Result on the web
<a href="https://www.mdpi.com/2077-0383/10/12/2640" target="_blank" >https://www.mdpi.com/2077-0383/10/12/2640</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jcm10122640" target="_blank" >10.3390/jcm10122640</a>

Result language
angličtina
Original language name
The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer
Original language description
Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age >= 60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine

Project
<a href="/en/project/NU21-09-00031" target="_blank" >NU21-09-00031: Development of new effective strategy to identify high-risk women for endometrial cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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