Significant current epidemiological trend: Haematological malignancies as subsequent primary tumours in cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074426" target="_blank" >RIV/65269705:_____/21:00074426 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/21:00078675 RIV/00216224:14110/21:00121472

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1877782121000461" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1877782121000461</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canep.2021.101929" target="_blank" >10.1016/j.canep.2021.101929</a>

Result language

angličtina

Original language name

Significant current epidemiological trend: Haematological malignancies as subsequent primary tumours in cancer patients

Original language description

Background: Numbers of patients who develop subsequent primary tumours have markedly increased recently. This study aimed to carry out a comprehensive analysis documenting the risk of incidence of subsequent haematological malignancies. Methods: The Czech National Cancer Registry was the main data source, containing records of 126,822 haematological malignancies diagnosed in the period 1977-2016. Subsequent haematological malignancies were identified according to IACR rules. Joinpoint regression was employed to assess the time trends. The risk of development of subsequent haematological malignancy was evaluated by the standardised incidence ratio. The Kaplan-Meier curves were used to assess the differences in survival. Results: Age-standardised incidence of subsequent haematological malignancies increased from 0.5 in 1977 to 9.1 in 2016. In 1992, there was a significant change in the trend: a sharp increase by 7.7 % annually was revealed thereafter. The risk of development of a haematological malignancy was approximately 1.5 times higher in persons with history of any cancer than in the general Czech population. Patients with haematological malignancies-mainly myelodysplastic syndromes, polycythaemia vera and non-Hodgkin lymphoma-were shown to be at the highest risk of developing a subsequent haematological malignancy. While the median survival following a first haematological malignancy was 2.3 years, it was only 1.1 years for subsequent haematological malignancies (p &lt; 0.001). Conclusions: Our study identified the highest-risk diagnoses in terms of development of subsequent haematological malignancy. The results might be useful to set up correctly follow-up procedures from which cancer patients could benefit.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Epidemiology

ISSN

1877-7821

e-ISSN

—

Volume of the periodical

72

Issue of the periodical within the volume

JUN

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

101929

UT code for WoS article

000652749700004

EID of the result in the Scopus database

2-s2.0-85103668664