Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074476" target="_blank" >RIV/65269705:_____/21:00074476 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00120121
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=7126&session_id=ht7cujnssakm485s6kr6c0eqb1" target="_blank" >http://www.elis.sk/download_file.php?product_id=7126&session_id=ht7cujnssakm485s6kr6c0eqb1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2021_200814N861" target="_blank" >10.4149/neo_2021_200814N861</a>
Alternative languages
Result language
angličtina
Original language name
Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant
Original language description
Despite the high efficacy of current induction regimens, most multiple myeloma (MM) patients relapse over time. The link between changes in the immune system and the prognosis of the disease is still not entirely clear. Therefore, we analyzed whether the pattern of bone marrow (BM) lymphocytes during routine BM examination after autologous stem cell transplant (ASCT) is related to disease prognosis or MRD negative complete remission. From 2009 to 2018, 98 MM patients underwent routine BM testing after the first ASCT. Using multi-parametric flow cytometry, twelve BM lymphocyte subtypes were analyzed. In 60% of patients who achieved a complete response (CR), MRD by flow cytometric analysis (sensitivity threshold 10-6) was evaluated. We found an association of relative proportion of BM lymphocyte subtypes with treatment response, progression-free survival (PFS), overall survival (OS), and minimal residual disease (MRD) negativity. Higher relative proportion of memory B cells was associated with inferior median PFS [HR 1.089 (95% CI: 1.023-1.160), p=0.0081 and median OS [HR 1.170 (95% CI: 1.074-1.274), p<0.001]. In non-responding patients (minimal response and worse), higher proportion of memory B cells was found when compared to patients achieving CR [3.8% (range 0.5-35.0) vs. 1.0% (range 0.1-12.5); p=0.0011. No significant association of BM lymphocyte subtypes proportion with MRD negative CR was found. Our results show that changes in BM lymphocyte subsets including memory B cells may have prognostic value in MM patients after ASCT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NV17-29343A" target="_blank" >NV17-29343A: Bone marrow microenvironment analysis in extramedullary relapse of multiple myeloma</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
—
Volume of the periodical
68
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
519-527
UT code for WoS article
000662144000007
EID of the result in the Scopus database
2-s2.0-85107390421