Gut microbiota and autism spectrum disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074527" target="_blank" >RIV/65269705:_____/21:00074527 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00124206

Result on the web

<a href="https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2021-2-9/strevni-mikrobiota-a-poruchy-autistickeho-spektra-127024?hl=en" target="_blank" >https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2021-2-9/strevni-mikrobiota-a-poruchy-autistickeho-spektra-127024?hl=en</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2021127" target="_blank" >10.48095/cccsnn2021127</a>

Result language

angličtina

Original language name

Gut microbiota and autism spectrum disorders

Original language description

Autism spectrum disorders (ASD) are neurodevelopmental and neuropsychiatric disorders with clinical manifestation in childhood, characterized by difficulties in social interaction and communication, limited interests, and repetitive behavior. In recent years, there has been a significant increase in the prevalence of this disorder, currently affecting 1-2% of children. In pathophysiology, genetic factors are mainly used, which are also modified in their phenotypic expression by environmental factors. A large percentage of patients with ASD also have a variety of gastrointestinal problems; children experience constipation or diarrhea, flatulence, or nonspecific abdominal pain. In last years, the connection of intestinal symptomatology with the manifestations of ASD has come to the forefront of scientific interest with the development of new molecular-biological methods of studying the community of intestinal microorganisms, the gut microbiota. Communication between the gut and the CNS (the gut-brain axis) is made possible by a very complex two-way neurohumoral communication system. This system ensures the effect of the intestinal microbiota on brain functions and allows the brain signals to affect the intestinal microbiota activity and the gastrointestinal tract functions. This article focuses on various pathophysiological mechanisms involved in these processes and discusses in detail the possible therapeutic modalities that affect the gut microbiota composition and function, such as the use of vancomycin, oxytocin, prebiotics and probiotics, as well as fecal transplantation, which has very promising results in relation to both gastrointestinal and ASD symptoms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Volume of the periodical

84

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

127-134

UT code for WoS article

000694710200002

EID of the result in the Scopus database

2-s2.0-85108081970