Protein C-MYB: A new prognostic factor in osteosarcoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074536" target="_blank" >RIV/65269705:_____/21:00074536 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/28/showToc" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/28/showToc</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Protein C-MYB: A new prognostic factor in osteosarcoma
Original language description
Aberrant activation of the transcription factor c-Myb promotes cell proliferation and survival, thereby contributing to malignant transformation. Recent studies described its role in bone development and growth as well as its expression in osteosarcoma cell lines but the relevance of c-Myb in control of osteosarcoma development, progression and chemoresistance remained unknown. Our results revealed the importance of c-Myb in regulation of osteosarcoma cell line chemosensitivity and metastatic activity and disclosed c-Myb as a negative prognostic factor for osteosarcoma patients.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NV18-07-00073" target="_blank" >NV18-07-00073: c-Myb and its transcriptional program in physiological and pathological osteogenic processes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů