The Role of Circulating MicroRNAs in Patients with Early-Stage Pancreatic Adenocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074596" target="_blank" >RIV/65269705:_____/21:00074596 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/21:00078876 RIV/00216224:14110/21:00122646
Result on the web
<a href="https://www.mdpi.com/2227-9059/9/10/1468" target="_blank" >https://www.mdpi.com/2227-9059/9/10/1468</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines9101468" target="_blank" >10.3390/biomedicines9101468</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Circulating MicroRNAs in Patients with Early-Stage Pancreatic Adenocarcinoma
Original language description
Pancreatic ductal adenocarcinoma (PDAC) is increasing in incidence and is still associated with a high rate of mortality. Only a minority of patients are diagnosed in the early stage. Radical surgery is the only potential curative procedure. However, radicality is reached in 20% of patients operated on. Despite the multidisciplinary approach in resectable tumors, early tumor recurrences are common. Options on how to select optimal candidates for resection remain limited. Nevertheless, accumulating evidence shows an important role of circulating non-coding plasma and serum microRNAs (miRNAs), which physiologically regulate the function of a target protein. miRNAs also play a crucial role in carcinogenesis. In PDAC patients, the expression levels of certain miRNAs vary and may modulate the function of oncogenes or tumor suppressor genes. As they can be detected in a patient's blood, they have the potential to become promising non-invasive diagnostic and prognostic biomarkers. Moreover, they may also serve as markers of chemoresistance. Thus, miRNAs could be useful for early and accurate diagnosis, prognostic stratification, and individual treatment planning. In this review, we summarize the latest findings on miRNAs in PDAC patients, focusing on their potential use in the early stage of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
1468
UT code for WoS article
000716958200001
EID of the result in the Scopus database
2-s2.0-85118336906