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Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074733" target="_blank" >RIV/65269705:_____/21:00074733 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/21:00120082

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/ejp.1695" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ejp.1695</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ejp.1695" target="_blank" >10.1002/ejp.1695</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis

  • Original language description

    Background Central neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles in MS patients with CNEP. Methods In a single-centre observational study, a group of 56 CNEP MS patients was compared with 63 pain-free MS patients and with a sex- and age-adjusted control group. Standardized quantitative sensory testing (QST) and dynamic QST (dQST) protocols comprising temporal summation and conditioned pain modulation tests were used to compare sensory profiles. Results Loss-type QST abnormalities in both thermal and mechanical QST modalities prevailed in both MS subgroups and correlated significantly with higher degree of disability expressed as Expanded Disability Status Scale (EDSS). Comparison of sensory phenotypes disclosed a higher frequency of the &apos;sensory loss&apos; prototypic sensory phenotype in the CNEP subgroup (30%) compared with pain-free MS patients (6%; p = .003). Conclusion The role of aging process and higher lesion load in the spinothalamocortical pathway might be possible explanation for pain development in this particular &apos;deafferentation&apos; subtype of central neuropathic pain in MS. We were unable to support the role of central sensitization or endogenous facilitatory and inhibitory mechanisms in the development of CNEP in MS. Significance This article presents higher prevalence of the &apos;sensory loss&apos; prototypic sensory phenotype in multiple sclerosis patients with central extremity neuropathic pain compared to pain-free patients. Higher degree of disability underlines the possible role of higher lesion load in the somatosensory pathways in this particular &apos;deafferentation&apos; type of central neuropathic pain.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European journal of pain

  • ISSN

    1090-3801

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    22

  • Pages from-to

    573-594

  • UT code for WoS article

    000592953400001

  • EID of the result in the Scopus database

    2-s2.0-85096867488