The Clinical Significance of Circulating Microparticles Concerning Thrombosis in BCR/ABL1-negative Myeloproliferative Neoplasms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074821" target="_blank" >RIV/65269705:_____/21:00074821 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00122607

Result on the web

<a href="https://iv.iiarjournals.org/content/35/6/3345" target="_blank" >https://iv.iiarjournals.org/content/35/6/3345</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/invivo.12632" target="_blank" >10.21873/invivo.12632</a>

Result language

angličtina

Original language name

The Clinical Significance of Circulating Microparticles Concerning Thrombosis in BCR/ABL1-negative Myeloproliferative Neoplasms

Original language description

Background/Aim: This work aimed to prospectively evaluate the clinical significance of circulating microparticles (MPs) in relation to thrombotic risk factors and thrombotic complications in patients with BCR/ABL1-negative myeloproliferative neoplasms (MPN). Patients and Methods: In a cohort of 206 patients with MPN, MPs&apos; procoagulant activity was measured by the Zymuphen functional assay in 429 samples, while plateletand erythrocyte-MPs were enumerated by flow cytometry in 558 samples. Results: MPN patients had higher MP levels than the control group. The levels of MPs were higher in male patients, smokers, and those who were older than 60 years, and in the presence of JAK2(V)(617F) mutation, history of thrombosis, platelets &gt;400 x 10(9)/l, hematocrit &gt;45%, or leukocytes &gt;10x 10(9)/l. Cytoreductive treatment reduced MP levels, with anagrelide being associated with lower MP levels than hydroxyurea. Conclusion: The relationship with thrombotic risk factors indicates a possible role of MPs in the complex thrombotic mechanism, though cytoreductive treatment seems to affect this role through reducing MP levels.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

In Vivo

ISSN

0258-851X

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

6

Country of publishing house

GR - GREECE

Number of pages

9

Pages from-to

3345-3353

UT code for WoS article

000711693300017

EID of the result in the Scopus database

2-s2.0-85119254439