Liver cirrhosis and pregnancy: a case report and review of literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074862" target="_blank" >RIV/65269705:_____/21:00074862 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00121767

Result on the web

<a href="https://www.casopisvnitrnilekarstvi.cz/artkey/vnl-202103-0015_liver-cirrhosis-and-pregnancy-a-case-report-and-review-of-literature.php" target="_blank" >https://www.casopisvnitrnilekarstvi.cz/artkey/vnl-202103-0015_liver-cirrhosis-and-pregnancy-a-case-report-and-review-of-literature.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.36290/vnl.2021.048" target="_blank" >10.36290/vnl.2021.048</a>

Result language

angličtina

Original language name

Liver cirrhosis and pregnancy: a case report and review of literature

Original language description

Liver cirrhosis is a chronic liver disease in which the liver tissue and the vascular beds are remodeled leading to impaired hepatic function. Portal hypertension and subsequent esophageal varices are a frequent complication of liver cirrhosis and are a cause of mortality in patients with liver cirrhosis. Pregnancy in women with liver cirrhosis is uncommon, the incidence being about 1 in 5 950 pregnancies. Hepatocellular damage and the associated alteration in the metabolism of the sex hormones is thought to be responsible and leads to anovulation. In spite of all these factors, women with cirrhosis can and do become pregnant. Pregnancy is successful in most of the patients with chronic liver disease, but maternal and fetal complication rates are still high for decompensated liver cirrhosis. Portal hypertension associated with pregnancy is a high-risk situation as both pregnancy and portal hypertension share some of the hemodynamic changes. Risks of variceal bleeding and hepatic decompensation increases many fold during pregnancy. Despite the possible complications mentioned above, the maternal-fetal morbidity and mortality rates have been decreased by the current developments in hepatology, prevention of bleeding from varices with drugs and/or endoscopic variceal ligation, improvement in liver transplantation, and an increased experience in these issues. We present a case of a 31-year-old female patient with liver cirrhosis who successfully managed pregnancy and birth without complications after the insertion of transjugular intrahepatic portosystemic shunt (TIPS). Unfortunately, 2 years after delivery, the patient developed lymphoblastic lymphoma and, despite intensive therapy for this disease, the patient died at the age of 40. We did not find any link between liver cirrhosis and lymphoblastic lymphoma.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30200 - Clinical medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vnitřní lékařství

ISSN

0042-773X

e-ISSN

—

Volume of the periodical

67

Issue of the periodical within the volume

E-3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

28-32

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85111784803