GAB1 – Novel Regulator of Migration Capacity and Tonic AKT Activity in CLL: Implications for Combinatorial Therapy With BCR Inhibitors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075055" target="_blank" >RIV/65269705:_____/21:00075055 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/abs/10.1080/10428194.2021.1995175" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/10428194.2021.1995175</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10428194.2021.1995175" target="_blank" >10.1080/10428194.2021.1995175</a>

Result language
angličtina
Original language name
GAB1 – Novel Regulator of Migration Capacity and Tonic AKT Activity in CLL: Implications for Combinatorial Therapy With BCR Inhibitors
Original language description
Introduction: CLL cell recirculation between peripheral blood and immune niches has been proposed as an important feature of CLL pathophysiology. However, it remains unknown how precisely CLL cells regulate their homing or how they balance survival in peripheral blood and the decision to return to immune niches. It has been hypothesized that the CLL cell recirculation can be studied by analyzing CXCR4/CD5 intraclonal CLL subpopulations (Calissano et al., 2011; Pavlasova et al., 2016). Here, we aim to identify and functionally characterize novel regulators of CLL cell migration.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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