The biology of miRNAs in B cell malignancies and their use as biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075109" target="_blank" >RIV/65269705:_____/21:00075109 - isvavai.cz</a>
Result on the web
<a href="http://precisiondiagnostics.eu/programme/" target="_blank" >http://precisiondiagnostics.eu/programme/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The biology of miRNAs in B cell malignancies and their use as biomarkers
Original language description
B Cell Receptor (BCR) signalling is fundamental for the maturation, survival, and proliferation of B cells, and B cell malignancies frequently harbour mutations in this pathway or complex nongenetic deregulation of BCR signalling. This pathway cross-talks with other essential pathways in the microenvironment of malignant B cells, especially B-T cell interactions and cell adhesion. This is underscored by the remarkable clinical effect of inhibitors targeting BCR-associated kinases BTK and PI3K, especially in chronic lymphocytic leukaemia (CLL). The differences in BCR signalling propensity contribute to variable prognosis in CLL and other "mature" B cell malignancies, and it has been shown that non-coding RNAs such as miR-150, miR-155, miR-34a or miR-17-92 play an important role in this process. The talk will focus on novel roles of microRNAs (miRNAs) in fine tuning the propensity of BCR signalling during microenvironmental interactions of B cells, and also the related changes during therapy with BCR inhibitors or classical DNA-damaging therapeutic drugs. This will include novel data on MYC-regulated and p53-regulated miRNAs acting as regulators of survival and proliferation of malignant B cells. The understanding of these miRNA functions allowed the development of several patented miRNA-based biomarkers that can be used to predict therapeutic response and/or overall survival in B cell malignancies such as chronic lymphocytic leukaemia and follicular lymphoma.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů