On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075865" target="_blank" >RIV/65269705:_____/21:00075865 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00121375
Result on the web
<a href="https://www.exeley.com/acta_neurobiologiae_experimentalis/doi/10.21307/ane-2021-009" target="_blank" >https://www.exeley.com/acta_neurobiologiae_experimentalis/doi/10.21307/ane-2021-009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21307/ane-2021-009" target="_blank" >10.21307/ane-2021-009</a>
Alternative languages
Result language
angličtina
Original language name
On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study
Original language description
Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Neurobiologiae Experimentalis
ISSN
0065-1400
e-ISSN
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Volume of the periodical
81
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
16
Pages from-to
80-95
UT code for WoS article
000635355400008
EID of the result in the Scopus database
2-s2.0-85103989271