Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076140" target="_blank" >RIV/65269705:_____/22:00076140 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/22:10444210 RIV/00179906:_____/22:10444210 RIV/00216224:14110/22:00128220

Result on the web

<a href="https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/view/83418" target="_blank" >https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/view/83418</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/PJNNS.a2021.0078" target="_blank" >10.5603/PJNNS.a2021.0078</a>

Result language

angličtina

Original language name

Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Original language description

Although still rare, there have been reports describing autoimmune demyelinating disorders associated with specific antibodies which overlap with multiple sclerosis (MS) and other demyelinating syndromes in clinical, radiological and immunological features. A relationship between anti-myelin-associated glycoprotein (MOG) syndrome, anti-aquaporin-4 (AQ-4) neuromyelitis optica spectrum disorders, and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been described. The opportunity of discovering yet unknown associations is based on the presumption of the co-occurrence of immune mediated diseases [1]. The association of multiple sclerosis with glutamic acid decarboxylase (GAD) neurological syndromes has only been reported in one case [2, 3]. The associated neurological syndromes include stiff-person syndrome (SPS), cerebellar ataxia, epilepsy, and limbic encephalitis. Paraneoplastic origin is rare, and comorbidities include autoimmune thyreoiditis, pernicious anaemia and vitiligo [4]. More than 85% of patients with anti-Hu antibodies harbour small cell lung cancer (SCLC) or, less frequently, other tumours. Anti-Hu antibodies can be found in the sera of 2% of patients without a tumour after five years, but these antibodies are not detected in normal subjects or in other neurological disorders [5]. We present one case of non-paraneoplastic anti-Hu brainstem syndrome and one case of progressive GAD ataxia syndrome associated with primary progressive multiple sclerosis (PP-MS).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurologia i Neurochirurgia Polska

ISSN

0028-3843

e-ISSN

1897-4260

Volume of the periodical

56

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

4

Pages from-to

187-190

UT code for WoS article

000793942800001

EID of the result in the Scopus database

2-s2.0-85129780993