QRS micro-fragmentation as a mortality predictor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076407" target="_blank" >RIV/65269705:_____/22:00076407 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/22:00127066

Result on the web

<a href="https://academic.oup.com/eurheartj/article/43/40/4177/6533247" target="_blank" >https://academic.oup.com/eurheartj/article/43/40/4177/6533247</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/ehac085" target="_blank" >10.1093/eurheartj/ehac085</a>

Result language

angličtina

Original language name

QRS micro-fragmentation as a mortality predictor

Original language description

Aims Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and to signify risk of cardiac events. Depolarization abnormalities with similar prognostic implications likely exist beyond visual recognition but no technology is presently suitable for quantification of such invisible ECG abnormalities. We present such a technology. Methods and results A signal processing method projects all ECG leads of the QRS complex into optimized three perpendicular dimensions, reconstructs the ECG back from this three-dimensional projection, and quantifies the difference (QRS &apos;micro&apos;-fragmentation, QRS-mu f) between the original and reconstructed signals. QRS &apos;micro&apos;-fragmentation was assessed in three different populations: cardiac patients with automatic implantable cardioverter-defibrillators, cardiac patients with severe abnormalities, and general public. The predictive value of QRS-mu f for mortality was investigated both univariably and in multivariable comparisons with other risk factors including visible QRS &apos;macro&apos;-fragmentation, QRS-Mf. The analysis was made in a total of 7779 subjects of whom 504 have not survived the first 5 years of follow-up. In all three populations, QRS-mu f was strongly predictive of survival (P &lt; 0.001 univariably, and P &lt; 0.001 to P = 0.024 in multivariable regression analyses). A similar strong association with outcome was found when dichotomizing QRS-mu f prospectively at 3.5%. When QRS-mu f was used in multivariable analyses, QRS-Mf and QRS duration lost their predictive value. Conclusion In three populations with different clinical characteristics, QRS-mu f was a powerful mortality risk factor independent of several previously established risk indices. Electrophysiologic abnormalities that contribute to increased QRS-mu f values are likely responsible for the predictive power of visible QRS-Mf. Key question The cardiac risk associated with visually diagnosed QRS fragmentation suggests that important QRS abnormalities might exist below the resolution of visual detection. Nevertheless, at present, little possibility exists to detect &apos;invisible&apos; abnormalities of myocardial depolarization. Key finding QRS &apos;micro-fragmentation&apos;, QRS- analysis quantifies &apos;invisible&apos; abnormalities of myocardial depolarization. It was found to independently predict death in three different populations of a total of 7779 subjects of whom 504 have not survived the first 5 years of follow-up. Take-home message QRS-mu f is a strong predictor of worsened survival. It can be assessed in standard short-term 12-lead electrocardiograms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Heart Journal

ISSN

0195-668X

e-ISSN

1522-9645

Volume of the periodical

43

Issue of the periodical within the volume

40

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

4177-4191

UT code for WoS article

000758231400001

EID of the result in the Scopus database

2-s2.0-85138245396