Malignant complications of celiac disease: a case series and review of the literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076583" target="_blank" >RIV/65269705:_____/22:00076583 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/22:43924423 RIV/00216224:14110/22:00128049 RIV/00064190:_____/22:N0000021

Result on the web

<a href="https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-022-03682-3" target="_blank" >https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-022-03682-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13256-022-03682-3" target="_blank" >10.1186/s13256-022-03682-3</a>

Result language

angličtina

Original language name

Malignant complications of celiac disease: a case series and review of the literature

Original language description

BackgroundCeliac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Diagnosis is based on evaluating specific autoantibodies and histopathologic findings of duodenal biopsy specimens. The only therapy for celiac disease is a gluten-free diet. Celiac disease can be complicated by malnutrition, other autoimmune diseases, refractoriness to treatment, and gastrointestinal tumors. This article presents seven cases of malignancies in patients with celiac disease. Its objective is to raise awareness of the malignant complications of celiac disease, leading to earlier diagnosis and improved outcomes. Case presentationSeven cases of malignant complications of celiac disease occurred among 190 patients followed at the Department of Internal Medicine and Gastroenterology, University Hospital Brno from 2014 to 2021. We describe these cases and the presentation, diagnostic process, course, management, and outcomes for each, along with proposed potential risk factors of malignant complications. There was one Caucasian man who was 70 years old and six Caucasian women who were 36, 46, 48, 55, 73, and 82 years old in our cohort. Of the seven cases of malignancies in our cohort, four patients were diagnosed with small bowel adenocarcinoma, one with diffuse large B-cell lymphoma, one with carcinoma of the tongue, and one with colorectal carcinoma. ConclusionsMalignancies occurred in 3.7% of patients followed up for celiac disease. Awareness of the malignant complications of celiac disease, risk factors, presentation, and disease course could lead to earlier diagnosis and improved outcomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Medical Case Reports

ISSN

1752-1947

e-ISSN

1752-1947

Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

460

UT code for WoS article

000897934500001

EID of the result in the Scopus database

2-s2.0-85143684249