CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients-Recommendations Proposal

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00077364" target="_blank" >RIV/65269705:_____/22:00077364 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/22:00126527 RIV/61988987:17110/22:A2302GYU

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmed.2022.854280/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmed.2022.854280/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2022.854280" target="_blank" >10.3389/fmed.2022.854280</a>

Result language

angličtina

Original language name

CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients-Recommendations Proposal

Original language description

To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient&apos;s individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors (PPIs) are the first-choice drugs in intensive care unit patients. The degradation of proton pump inhibitors is mediated by cytochrome P450 (CYP) enzymes; in particular, CYP2C19 and, to a lesser extent, CYP3A4 are involved. Expression and metabolic activity of, namely in, CYP2C19 is significantly affected by single nucleotide polymorphisms, the drug metabolization rate varies greatly from ultrarapid to poor and likely influences the optimal dosage. As these CYP2C19 predictive phenotypes via CYP2C19 haplogenotypes (rs12248560/rs4244285) can be relatively easily determined using the current standard equipment of hospital laboratories, we prepared a set of recommendations for personalized PPI-based stress ulcer prophylaxis taking into account the patient&apos;s CYP2C19 predictive phenotype determined in this way. These recommendations are valid, in particular, for European, American and African populations, because these populations have the high representations of the CYP2C19*17 allele associated with the overexpression of the CYP2C19 gene and ultrarapid degradation of PPIs. We propose the CYP2C19 gene profiling as a tool for personalized SUP with PPI in critically ill patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in medicine

ISSN

2296-858X

e-ISSN

2296-858X

Volume of the periodical

9

Issue of the periodical within the volume

Jul

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

854280

UT code for WoS article

000832805500001

EID of the result in the Scopus database

2-s2.0-85134699817