Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00077818" target="_blank" >RIV/65269705:_____/23:00077818 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130366

Result on the web

<a href="https://karger.com/psp/article/56/5/403/836044/Peripheral-Inflammatory-Markers-in-Subtypes-and" target="_blank" >https://karger.com/psp/article/56/5/403/836044/Peripheral-Inflammatory-Markers-in-Subtypes-and</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000528907" target="_blank" >10.1159/000528907</a>

Result language

angličtina

Original language name

Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review

Original language description

Introduction: The aim of this work was to summarize relationships between two subtypes of major depressive disorder (melancholic and atypical) and four core features of depression that reflect the domains identified consistently in previous studies of major depressive disorder endophenotypes (exaggerated reactivity to negative information, altered reward processing, cognitive control deficits, and somatic symptoms) on the one hand and selected peripheral inflammatory markers (C-reactive protein [CRP], cytokines, and adipokines) on the other. Methods: A systematized review was conducted. The database used for searching articles was PubMed (MEDLINE). Results: According to our search, most peripheral immunological markers associated with major depressive disorder are not specific to a single depressive symptom group. The most evident examples are CRP, IL-6, and TNF-alpha. The strongest evidence supports the connection of peripheral inflammatory markers with somatic symptoms; weaker evidence indicates a role of immune changes in altered reward processing. The least amount of evidence was found for the role of peripheral inflammatory markers in exaggerated reactivity to negative information and cognitive control deficits. Regarding the depression subtypes, a tendency for higher CRP and adipokines was observed in atypical depression; increased IL-6 was found in melancholic depression. Conclusion: Somatic symptoms of depression could be a manifestation of a specific immunological endophenotype of depressive disorder. Melancholic and atypical depression may be characterized by different profiles of immunological markers.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychopathology

ISSN

0254-4962

e-ISSN

1423-033X

Volume of the periodical

56

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

403-416

UT code for WoS article

000937204300001

EID of the result in the Scopus database

2-s2.0-85149299386