Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078266" target="_blank" >RIV/65269705:_____/23:00078266 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/23:96668 RIV/00216224:14110/23:00131350 RIV/61989592:15110/23:73622102
Result on the web
<a href="https://www.mdpi.com/2075-4418/13/15/2468" target="_blank" >https://www.mdpi.com/2075-4418/13/15/2468</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/diagnostics13152468" target="_blank" >10.3390/diagnostics13152468</a>
Alternative languages
Result language
angličtina
Original language name
Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
Original language description
The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostics
ISSN
2075-4418
e-ISSN
2075-4418
Volume of the periodical
13
Issue of the periodical within the volume
15
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
2468
UT code for WoS article
001045385400001
EID of the result in the Scopus database
2-s2.0-85167697675