Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078509" target="_blank" >RIV/65269705:_____/23:00078509 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00132253

Result on the web

<a href="https://bmjpaedsopen.bmj.com/content/bmjpo/7/1/e002172.full.pdf" target="_blank" >https://bmjpaedsopen.bmj.com/content/bmjpo/7/1/e002172.full.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/bmjpo-2023-002172" target="_blank" >10.1136/bmjpo-2023-002172</a>

Result language

angličtina

Original language name

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Original language description

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC&apos;s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMJ Paediatrics Open

ISSN

2399-9772

e-ISSN

2399-9772

Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

"e002172"

UT code for WoS article

001099840500001

EID of the result in the Scopus database

2-s2.0-85177452191