Changes in Gene Expression in Pressure Ulcers Debrided by Different Approaches - a Pilot Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00079446" target="_blank" >RIV/65269705:_____/23:00079446 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00134692
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2023/72_S535.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2023/72_S535.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935222" target="_blank" >10.33549/physiolres.935222</a>
Alternative languages
Result language
angličtina
Original language name
Changes in Gene Expression in Pressure Ulcers Debrided by Different Approaches - a Pilot Study
Original language description
Pressure ulcers (PUs), also known as pressure injuries, are chronic wounds that represent potential lifelong complications. Pressure ulcers of a deep category (III and IV) are often indicated for surgical treatment - debridement and surgical reconstruction. Sharp surgical debridement is widely used in the debridement of PUs; however, the Versajet (R) hydrosurgery system is becoming an increasingly popular tool for tangential excision in surgery due to its numerous advantages. This work focused on the expression of selected genes, especially those associated with oxidative stress, in PUs debrided by two approaches - sharp surgical debridement and debridement using Versajet (R) hydrosurgery system. Expression of following genes was evaluated: NFE2L2, ACTA2, NFKB1, VEGFA, MKI67, HMOX1, HMOX2, HIF1A, and SOD2. ACTB and PSMB were used as housekeeping genes. So far, five patients have been enrolled in the study. Preliminary results suggest no significant difference in gene expression with different pressure ulcer treatment approaches except NFE2L2, despite the macroscopic differences. However, the results revealed correlations between the expression of some genes, namely HIF1A and SOD2, VEGFA and SOD2 and VEGFA and HIF1A. These results may indicate a connection between hypoxia, oxidative stress, pressure ulcer healing processes and angiogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
<a href="/en/project/NU21-09-00541" target="_blank" >NU21-09-00541: The role of oxidative stress in the healing of pressure ulcers in patients with spinal cord lesions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
72
Issue of the periodical within the volume
Suppl 5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
"S535"-"S542"
UT code for WoS article
001198072000009
EID of the result in the Scopus database
2-s2.0-85181543958