Denosumab-related osteonecrosis of the external auditory canal-benefit of the early surgical management
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00077948" target="_blank" >RIV/65269705:_____/24:00077948 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00134971 RIV/00098892:_____/24:10157555
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/01455613211053389" target="_blank" >https://journals.sagepub.com/doi/10.1177/01455613211053389</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/01455613211053389" target="_blank" >10.1177/01455613211053389</a>
Alternative languages
Result language
angličtina
Original language name
Denosumab-related osteonecrosis of the external auditory canal-benefit of the early surgical management
Original language description
Background: Antiresorptive drugs are widely used to reduce bone mineral loss in patients with osteoporosis and to prevent skeletal-related events in patients with metastatic cancers and multiple myeloma (MM). Both the bisphosphonates (BP) and denosumab typically used in this indication were shown to be effective and relatively safe. Obviously, this medication could have some adverse effects; one of them is osteonecrosis of the external auditory canal. Only sporadic cases of external auditory canal osteonecrosis have been published yet. Here, we provide a case of denosumab-related osteonecrosis of the external auditory canal successfully treated surgically in the early stage of the disease. Case report: A 68-year-old patient with breast cancer underwent comprehensive oncological treatment, including denosumab administration. She was diagnosed with osteonecroses in the jaw and ear canal. The necrotic bones in both regions were resected with primary wound closure. Both affected sites healed well with no signs of necrosis recurrence. Conclusions: Osteonecrosis of the external auditory canal is a rare but probably underdiagnosed complication of antiresorptive medication. It has a negative impact on patient quality of life if left untreated. Early surgical treatment appears to be effective. The authors highlight several similarities with medication-related osteonecrosis of the jaw. Therefore, an analogous disease staging and treatment rationale is suggested.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ENT-Ear Nose & Throat Journal
ISSN
0145-5613
e-ISSN
1942-7522
Volume of the periodical
103
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
277-281
UT code for WoS article
000710707200001
EID of the result in the Scopus database
2-s2.0-85117496680