Consecutive or selectively included high bleeding risk patients in the MASTER DAPT screening log and trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00079884" target="_blank" >RIV/65269705:_____/24:00079884 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136841
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0953620524001766?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0953620524001766?pes=vor</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejim.2024.04.016" target="_blank" >10.1016/j.ejim.2024.04.016</a>
Alternative languages
Result language
angličtina
Original language name
Consecutive or selectively included high bleeding risk patients in the MASTER DAPT screening log and trial
Original language description
Aims: Screening logs have the potential to appraise the actual prevalence and distribution of predefined patient subsets, avoiding selection biases, which are inevitably and potentially present in randomised trials and real-world registries, respectively. We aimed to assess the prevalence of high bleeding risk (HBR) characteristics in the real world and the external validity of the MASTER DAPT trial. Methods and results: All consecutive patients who underwent percutaneous coronary intervention (PCI) for at least two consecutive weeks across 65 sites participating in the trial were entered into a screening log. Of 2,847 consecutive patients, 1,098 (38.6 %) were HBR and 109 (9.9 %) consented for trial participation. PRECISE-DAPT score GREATER-THAN OR EQUAL TO 25 was the most frequent HBR feature, followed by advanced age, use of oral anticoagulation (OAC) and anaemia. Compared with consecutive HBR patients, consenting patients were older (GREATER-THAN OR EQUAL TO 75 years: 69 % versus 62 %, absolute standardized difference [SD] 0.16), more frequently male (78 % versus 71 %, absolute SD 0.18), had higher use of OAC (38 % versus 20 %, absolute SD 0.39), treatment with steroids or nonsteroidal anti-inflammatory drugs (10 % versus 5 %, SD 0.16), and prior cerebrovascular events (10 % versus 6 %, absolute SD 0.18) but lower PRECISE DAPT score GREATER-THAN OR EQUAL TO 25 (54 % versus 66 %, absolute SD 0.24). Conclusions: The HBR criteria distribution differed between consecutive versus selectively included HBR patients, suggesting the existence of selection biases in the trial population.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30218 - General and internal medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Internal Medicine
ISSN
0953-6205
e-ISSN
1879-0828
Volume of the periodical
126
Issue of the periodical within the volume
AUG 2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
89-94
UT code for WoS article
001287622700001
EID of the result in the Scopus database
2-s2.0-85192096994