Risk factors and the severity of defect in patients with cleft lip and palate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00079896" target="_blank" >RIV/65269705:_____/24:00079896 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136427
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0165587624001216?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165587624001216?pes=vor</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijporl.2024.111967" target="_blank" >10.1016/j.ijporl.2024.111967</a>
Alternative languages
Result language
angličtina
Original language name
Risk factors and the severity of defect in patients with cleft lip and palate
Original language description
Orofacial clefts are one of the most common congenital malformations worldwide. The incidence of the newborns with orofacial clefts is approximately 1.7 in 1000 live births [1] and varies across regions, ethnicities, risk factors, and other variables. In the Czech Republic, the incidence is one cleft child in 600 healthy newborns [2]. Patients with cleft have higher mortality and morbidity than those without cleft [3,4]. Orofacial clefts have been extensively reviewed in previous literature [5]; the most common are nonsyndromic clefts [6] including cleft lip and palate (CLP), cleft lip (CL), and cleft palate (CP) alone [5]. According to a large European study, 71 % of cleft lip with or without cleft palate (CL/P) cases were isolated, whereas 29 % were linked to other anomalies. Associated malformations are more often reported in patients with CLP (34.0 %) than patients with CL (20.8 %) [7].Etiology of the orofacial clefts is multifactorial: both genetic and environmental factors can contribute to the disease [6]. Previous studies showed that smoking and alcohol or drug consumption during pregnancy, maternal obesity and diabetes, increased maternal and paternal age, and maternal exposure to air and water pollution during pregnancy can increase a child's risk of developing a cleft [8]. However, the impact of risk factors on the severity of cleft defects remains poorly understood.The aims of this study were to describe the epidemiological data of patients with CL/P who underwent CL surgery in the Cleft Center at the University Hospital Brno (UHB) from 2010 to 2020 and to assess the impact of various risk factors on cleft severity in patients with nonsyndromic CL/P.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pediatric Otorhinolaryngology
ISSN
0165-5876
e-ISSN
1872-8464
Volume of the periodical
181
Issue of the periodical within the volume
JUN 2024
Country of publishing house
IE - IRELAND
Number of pages
5
Pages from-to
111967
UT code for WoS article
001244431100001
EID of the result in the Scopus database
2-s2.0-85193425833