Reproductive outcomes after fertility-sparing surgery for cervical cancer - results of the multicenter FERTISS study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080343" target="_blank" >RIV/65269705:_____/24:00080343 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137169 RIV/00216208:11110/24:10485247 RIV/61989592:15110/24:73625764 RIV/00098892:_____/24:10158758 RIV/00064165:_____/24:10485247

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0090825824010916?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0090825824010916?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ygyno.2024.08.020" target="_blank" >10.1016/j.ygyno.2024.08.020</a>

Result language

angličtina

Original language name

Reproductive outcomes after fertility-sparing surgery for cervical cancer - results of the multicenter FERTISS study

Original language description

Introduction: Fertility-sparing treatment (FST) for patients with cervical cancer intends to achieve oncologic outcomes comparable to those after radical treatment while maximizing reproductive outcomes, including the ability to conceive and minimizing the risk of prematurity. Methodology: International multicentre retrospective FERTISS study focused on patients treated with FST analysed timing of FST relative to pregnancy, conception attempts and methods, abortion rates, prophylactic procedures reducing the risk of severe prematurity, pregnancy duration, and delivery mode. Results: Of the 733 patients treated at 44 centres in 13 countries, 49.7% attempted to conceive during median follow-up of 72 months and 22.6% (166/733) patients achieved a successful pregnancy. Success rate was significantly higher after non-radical surgery (63.2%; 122/193) compared to radical trachelectomy (25.7%; 44/171, p &lt; 0.001). Available perinatological data shows that 89.5% (111/124) of the patients became pregnant naturally. There was no significant difference in the abortion rate in the first pregnancy nor delivery success rates between non-radical and radical procedures patients. Preterm delivery (&lt;38 weeks gestation) occurred more frequently after radical than non-radical procedures (76.5% vs. 57.7%, p = 0.15). Almost all patients (97.3%; 73/75) who underwent regular ultrasound cervicometry in pregnancy with subsequent prophylactic procedures delivered a live fetus, compared to 30.6% (15/49) women without such management, p &lt; 0.001. Conclusion: Patients who underwent non-radical surgery had significantly higher pregnancy rates. Most pregnancies resulted in a viable fetus, but radical trachelectomy led to a higher rate of preterm births in the severe prematurity range. Half of the patients did not attempt pregnancy after FST. (C) 2024 Elsevier Inc.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gynecologic Oncology

ISSN

0090-8258

e-ISSN

1095-6859

Volume of the periodical

190

Issue of the periodical within the volume

NOV 2024

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

179-185

UT code for WoS article

001312918200001

EID of the result in the Scopus database

2-s2.0-85202148692