Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080352" target="_blank" >RIV/65269705:_____/24:00080352 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00137175
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0925492724001069?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925492724001069?pes=vor</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pscychresns.2024.111883" target="_blank" >10.1016/j.pscychresns.2024.111883</a>
Alternative languages
Result language
angličtina
Original language name
Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia
Original language description
Recent fMRI resting-state findings show aberrant functional connectivity within somatomotor network (SMN) in schizophrenia. Moreover, functional connectivity aberrations of the motor system are often reported to be related to the severity of psychotic symptoms. Thus, it is important to validate those findings and confirm their relationship with psychopathology. Therefore, we decided to take an entirely data-driven approach in our fMRI resting-state study of 30 chronic schizophrenia outpatients and 30 matched control subjects. We used independent component analysis (ICA), dual regression, and seed-based connectivity analysis. We found reduced functional connectivity within SMN in schizophrenia patients compared to controls and SMN hypoconnectivity with the cerebellum in schizophrenia patients. The latter was strongly correlated with the severity of alogia, one of the main psychotic symptoms, i.e. poverty of speech and reduction in spontaneous speech,. Our results are consistent with the recent knowledge about the role of the cerebellum in cognitive functioning and its abnormalities in psychiatric disorders, e.g. schizophrenia. In conclusion, the presented results, for the first time clearly showed the involvement of the cerebellum hypoconnectivity with SMN in the persistence and severity of alogia symptoms in schizophrenia. (C) 2024 The Authors
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychiatry Research-Neuroimaging
ISSN
0925-4927
e-ISSN
1872-7506
Volume of the periodical
345
Issue of the periodical within the volume
DEC 2024
Country of publishing house
IE - IRELAND
Number of pages
6
Pages from-to
111883
UT code for WoS article
001309486700001
EID of the result in the Scopus database
2-s2.0-85203011253