Brivaracetam use in children with epilepsy: A retrospective multicenter study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080421" target="_blank" >RIV/65269705:_____/24:00080421 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137304 RIV/00216208:11130/24:10484994 RIV/00064203:_____/24:10484994

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1059131124002462?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1059131124002462?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seizure.2024.08.022" target="_blank" >10.1016/j.seizure.2024.08.022</a>

Result language

angličtina

Original language name

Brivaracetam use in children with epilepsy: A retrospective multicenter study

Original language description

Purpose: This retrospective multicenter study aimed to assess the efficacy and safety of brivaracetam (BRV) in pediatric epilepsy. Methods: Our cohort consisted of 93 children (mean age 11.5 +- 7.5 years) with a wide spectrum of pediatric epilepsy, including epileptic encephalopathy and generalized epilepsy. Of these, 61 (60.4%) were diagnosed with focal epilepsy, 19 (15.8%) with generalized epilepsy, and 16 (15.8%) with combined epilepsy, while 8 patients (7.9%) had an unknown epilepsy type. The cohort included rare epilepsy syndromes: 8 patients with Lennox-Gastaut syndrome, 3 with Dravet syndrome, and 1 with Rasmussen syndrome. Patients had a history of various antiseizure medications (ASMs) (6.42 +- 3.15), and on average, were being treated with more than two (2.57 +- 1.16) drugs at the time of BRV deployment. Results: Retention rates were high, with 80.6% of patients adhering to treatment at 3 months, 66.7% at 6 months, and 45.2% at 12 months. In 29 patients (30.1%), BRV was added in an overnight switch from levetiracetam (LEV), resulting in a reduction of behavioral adverse effects (AEs) in 5 patients (17.2%). The response rate was 25.8% at 3 months, 16.1% at 6 months, and 17.2% at 12 months, with no responders in the epileptic encephalopathy group. Therapy tolerance was notable, with 70 patients (75.3%) reporting no AEs. Transient AEs occurred in 10 patients (10.7%), and in 13 cases (14.0%), the AEs warranted dose adjustment or discontinuation of BRV. Conclusion: Approximately one-fifth of pediatric patients with drug-resistant epilepsy responded to BRV, with the best response observed in patients with focal seizures. However, the impact on patients with epileptic encephalopathy was limited. (C) 2024

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Seizure-European Journal of Epilepsy

ISSN

1059-1311

e-ISSN

1532-2688

Volume of the periodical

121

Issue of the periodical within the volume

OCT 2024

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

243-252

UT code for WoS article

001321205400001

EID of the result in the Scopus database

2-s2.0-85204356798