The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080535" target="_blank" >RIV/65269705:_____/24:00080535 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00137720
Result on the web
<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1471450/full" target="_blank" >https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1471450/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmed.2024.1471450" target="_blank" >10.3389/fmed.2024.1471450</a>
Alternative languages
Result language
angličtina
Original language name
The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study
Original language description
Introduction The influence of various levels of sedation depth on motor evoked potentials (MEP) reproducibility in youth is still unclear because of a lack of data. We tested the hypothesis that a deeper level of total intravenous anesthesia (TIVA) [bispectral index (BIS) 40 +/- 5 compared to 60 +/- 5] can affect surgeon-directed MEP and their interpretation in youths.Methods All patients received TIVA combined with propofol and remifentanil. TIVA was initially maintained at a BIS level of 60 +/- 5. The sedation anesthesia was deepened to BIS level 40 +/- 5 before the skin incision. MEP were recorded and interpreted at both BIS levels. The primary endpoint was to evaluate the effect of the depth of sedation on the MEP reproducibility directed and interpreted by the surgical team in each patient separately. The secondary endpoint was to compare the relativized MEP parameters (amplitude and latency) in percentage at various levels of sedation in each patient separately. We planned to enroll 150 patients. Due to the COVID-19 pandemic, we decided to analyze the results of the first 50 patients.Results The surgical team successfully recorded and interpreted MEP in all 50 enrolled patients in both levels of sedation depth without any clinical doubts. The MEP parameters at BIS level 40 +/- 5, proportionally compared with the baseline, were latency 104% (97-110%) and the MEP amplitudes 84.5% (51-109%).Conclusion Preliminary data predict that deeper sedation (BIS 40 +/- 5) does not affect the surgical team's interpretation of MEP in youth patients. These results support that surgeon-directed MEP may be an alternative when neurophysiologists are unavailable.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30218 - General and internal medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Medicine
ISSN
2296-858X
e-ISSN
2296-858X
Volume of the periodical
11
Issue of the periodical within the volume
OCT 2024
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
1471450
UT code for WoS article
001352018100001
EID of the result in the Scopus database
2-s2.0-85208610011