Aseptic abscess syndrome as first manifestation of Crohn's disease - a case report

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00081947" target="_blank" >RIV/65269705:_____/25:00081947 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00141115

Result on the web

<a href="https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-025-05617-5" target="_blank" >https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-025-05617-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12887-025-05617-5" target="_blank" >10.1186/s12887-025-05617-5</a>

Result language

angličtina

Original language name

Aseptic abscess syndrome as first manifestation of Crohn's disease - a case report

Original language description

BackgroundThere exist multiple extraintestinal manifestations of inflammatory bowel disease. The most common are arthritis, aphthous stomatitis, or uveitis. Aseptic abscess syndrome is not usually included among these extraintestinal manifestations. In our case report, we present a rare case of aseptic abscess syndrome as the first manifestation of inflammatory bowel disease.Case presentationWe present the case of a 10-year-old girl whose only initial medical issue was recurrent submandibular lymphadenitis unresponsive to standard antibiotic therapy. A broad differential diagnosis was initiated to exclude an infectious etiology. Eventually, it was necessary to proceed with extirpation of the suspected lymph node. Histological examination showed suppurative granulomatous inflammation, so it was further examined for noninfectious cause. Blood tests revealed positivity of ASCA antibodies (Anti-Saccharomyces cerevisiae) in both IgA and IgG classes. Despite absence of typical gastrointestinal symptoms, bowel ultrasound was performed, followed by magnetic resonance enterography. Both showed inflammatory changes in the terminal ileum. Subsequent endoscopy of the gastrointestinal tract and histological examination of biopsy specimens confirmed a diagnosis of Crohn&apos;s disease with terminal ileum and rectum involvement. A standard treatment based on current guidelines led to remission without recurrence of lymphadenitis.ConclusionsIn cases of lymphadenitis that does not respond to standard antibiotic treatment, diagnosis of aseptic abscess syndrome should be considered as a potential etiology and, subsequently, inflammatory bowel disease should be investigated, given that this syndrome is associated with inflammatory bowel disease in as many as 70% of cases. To our knowledge, this is the first published case report describing aseptic abscess syndrome affecting cervical lymph nodes as an extraintestinal manifestation of pediatric Crohn&apos;s disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

<a href="/en/project/NU21-07-00285" target="_blank" >NU21-07-00285: Study on microbial dysbiosis and microRNA deregulation as a basis of the therapy individualization in pediatric patients with inflammatory bowel disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Pediatrics

ISSN

1471-2431

e-ISSN

1471-2431

Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

346

UT code for WoS article

001480182700003

EID of the result in the Scopus database

2-s2.0-105003950756