Nutritional and biochemical insights into multiple pressure ulcer management: a case report

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00081963" target="_blank" >RIV/65269705:_____/25:00081963 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00144727

Result on the web

<a href="https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1564879/full" target="_blank" >https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1564879/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2025.1564879" target="_blank" >10.3389/fnut.2025.1564879</a>

Result language

angličtina

Original language name

Nutritional and biochemical insights into multiple pressure ulcer management: a case report

Original language description

This case report presents a unique study focused on relationship between nutritional parameters, C-reactive protein (CRP), and the marker of oxidative stress 8-hydroxy-2 &apos;-deoxyguanosine (8-OHdG), in 61-year-old male paraplegic patient with multiple pressure ulcers. A multidisciplinary approach was essential for the timing of the successful reconstruction process. The patient had a history of paraplegia since 1999 due to a skiing accident with fractures of thoracic vertebrae (Th6-Th9), requiring spinal surgery. His medical background includes acute pancreatitis with biliary tract revisions, partial pancreatic resection, acute respiratory failure with tracheostomy, renal failure treated with hemodialysis, bronchopneumonia, pseudomembranous colitis, and hyperuricemia. The patient also underwent multiple surgical interventions, including treatment for ulnar nerve paresis, cholecystectomy, and multiple pressure ulcer reconstructions. The study describes the relationship between selected biochemical parameters and overall clinical status in a paraplegic patient with three deep pressure ulcers located in the left-sided ischial, trochanteric, and sacral regions during their multistage surgical therapy. The reconstructive procedure and collection of biological samples for determination of selected biochemical parameters were performed according to the same schedule: debridement of pressure ulcers at the beginning of the particular hospitalization and on the day of surgical reconstruction. The patient&apos;s severe condition was accompanied by decreased levels of both 8-OHdG and selected nutritional parameters (albumin, prealbumin, and total protein) and increased CRP levels at the beginning of the treatment process. The evaluation of the dynamics of the measured parameters during the gradual improvement of the patient&apos;s condition and the multistage reconstruction of pressure ulcers in six hospitalizations over a period of 17 months was continued resulting in the healing of all pressure ulcers. This case highlights the crucial importance of investigating selected biochemical parameters, with emphasis on 8-OHdG, and nutritional parameters, for the timing of surgical strategy and comprehensive therapy in patients with multiple pressure ulcers and severe, complex medical histories.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30308 - Nutrition, Dietetics

Project

<a href="/en/project/NU21-09-00541" target="_blank" >NU21-09-00541: The role of oxidative stress in the healing of pressure ulcers in patients with spinal cord lesions</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

APR 2025

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

1564879

UT code for WoS article

001483381100001

EID of the result in the Scopus database

2-s2.0-105004463447