Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00083295" target="_blank" >RIV/65269705:_____/25:00083295 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00142919

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.2147/OPTH.S556193" target="_blank" >https://www.tandfonline.com/doi/full/10.2147/OPTH.S556193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/OPTH.S556193" target="_blank" >10.2147/OPTH.S556193</a>

Result language

angličtina

Original language name

Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study

Original language description

Purpose: To evaluate the anatomical and functional effects of optic chiasm compression caused by a pituitary adenoma both before and after surgery.Patients and Methods: Short-term prospective study of 48 eyes from 24 patients who underwent radical surgery for pituitary adenoma. Comprehensive ophthalmological assessment was performed and OCT (optical coherence tomography) parameters (RNFL - retinal nerve fiber layer, GCL - ganglion cell layer, BMO-MRW - Bruch&apos;s membrane opening-minimum rim width) and BVCA (best corrected visual acuity) using ETDRS (Early Treatment Diabetic Retinopathy Study) chart were evaluated before surgery and 3 months after surgery. Results:Over time, a decline in RNFL was observed in circular scans of 3.5 mm, 4.1 mm, and 4.7 mm (p = 0.001- 0.04), as well as in GCL (p = 0.001- 0.022) and BMO-MRW (p = 0.001- 0.033). The median improvement in vision was 4 letters (IQR 0- 6) (p &lt; 0.001). A positive correlation between RNFL and visual improvement was found only in the TS (temporo-superior) sector in the 4.7 mm circle (p = 0.018). A negative correlation was observed between the difference between preoperative and normative RNFL and GCL values and the postoperative BCVA (RNFL p = 0.005- 0.046, GCL p = 0.009- 0.022).Conclusion:Following radical surgery all three OCT parameters show a significant decline. While the reduction between preoperative and postoperative values does not influence the final visual outcome, preoperative atrophy of the RNFL and the GCL is negatively correlated with postoperative BCVA. The BMO-MRW may represent a novel marker of compressive neuropathy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30207 - Ophthalmology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Ophthalmology

ISSN

1177-5483

e-ISSN

1177-5483

Volume of the periodical

19

Issue of the periodical within the volume

2025

Country of publishing house

NZ - NEW ZEALAND

Number of pages

13

Pages from-to

4433-4445

UT code for WoS article

001634810500001

EID of the result in the Scopus database

2-s2.0-105024192801