Insight into the pathogenesis of interstitial lung diseases and near-to-native lung fibrosis models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00083334" target="_blank" >RIV/65269705:_____/25:00083334 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143748 RIV/00159816:_____/25:00082352
Result on the web
<a href="https://link.springer.com/article/10.1186/s40001-025-03504-4" target="_blank" >https://link.springer.com/article/10.1186/s40001-025-03504-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40001-025-03504-4" target="_blank" >10.1186/s40001-025-03504-4</a>

Result language
angličtina
Original language name
Insight into the pathogenesis of interstitial lung diseases and near-to-native lung fibrosis models
Original language description
Interstitial lung diseases (ILDs) is a large and heterogeneous group of disorders with a variable degree of lung inflammation and lung fibrosis. In some ILDs, we can observe a progressive-fibrosing phenotype-PF-ILD (e.g., idiopathic pulmonary fibrosis, fibrotic phenotype of hypersensitivity pneumonitis, familial lung fibrosis, etc.). Lung fibrosis is characterized by overgrowth, stiffening, and scarring of tissues due to excess deposition of extracellular matrix. In some patients suffering from PF-ILD, progression and fatal outcomes occur despite treatment. Therefore, there is a great need for the development of lung fibrosis models that will help to understand and recapitulate the etiopathogenesis of the disease and may thus serve as tools for unraveling its underlying profibrotic mechanisms and potential therapeutic targets. In this review, we summarize ILD etiopathogenesis, current and novel therapeutic options, and discuss in vivo, ex vivo, and in vitro near-to-native lung fibrosis models, which help to elucidate specific processes within ILD pathophysiology.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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