Preparation and Biological Properties of Ring-Substituted Naphthalene-1-Carboxanilides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67179843%3A_____%2F14%3A00439627" target="_blank" >RIV/67179843:_____/14:00439627 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/14:43872697

Result on the web

<a href="http://dx.doi.org/10.3390/molecules190710386" target="_blank" >http://dx.doi.org/10.3390/molecules190710386</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules190710386" target="_blank" >10.3390/molecules190710386</a>

Result language

angličtina

Original language name

Preparation and Biological Properties of Ring-Substituted Naphthalene-1-Carboxanilides

Original language description

In this study, a series of twenty-two ring-substituted naphthalene-1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl) naphthalene-1-carboxamide, N-(3-methoxyphenyl) naphthalene-1-carboxamide, N-(3-methylphenyl) naphthalene-1-carboxamide, N-(4-methylphenyl) naphthalene-1-carboxamide and N-(3-fluorophenyl) naphthalene-1-carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EH - Ecology - communities

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

10386-10409

UT code for WoS article

000340036200104

EID of the result in the Scopus database

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