Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985556%3A_____%2F24%3A00597935" target="_blank" >RIV/67985556:_____/24:00597935 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/24:00597935 RIV/00216208:11310/24:10487414
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2589004224016766?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2589004224016766?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2024.110451" target="_blank" >10.1016/j.isci.2024.110451</a>
Alternative languages
Result language
angličtina
Original language name
Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building
Original language description
Meiotic spindles are critical to ensure chromosome segregation during gamete formation. Oocytes lack centrosomes and use alternative microtubule-nucleation mechanisms for spindle building. How these mechanisms are regulated is still unknown. Aurora kinase A (AURKA) is essential for mouse oocyte meiosis because in pro-metaphase I it triggers microtubule organizing-center fragmentation and its expression compensates for the loss of the two other Aurora kinases (AURKB/AURKC). Although knockout mouse models were useful for foundational studies, AURK spatial and temporal functions are not yet resolved. We provide high-resolution analyses of AURKA/AURKC requirements during meiotic spindle-building and identify the subcellular populations that carry out these functions: 1) AURKA is required in early spindle assembly and later for spindle stability, whereas 2) AURKC is required in late pro-metaphase, and 3) Targeted AURKA constructs expressed in triple AURK knockout oocytes reveal that spindle pole-localized AURKA is the most important population controlling spindle building and stability mechanisms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/GA23-07532S" target="_blank" >GA23-07532S: Regulation of acentriolar spindle assembly and chromosome segregation in human and mouse oocyte meiosis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
27
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
110451
UT code for WoS article
001270312300001
EID of the result in the Scopus database
2-s2.0-85198332961