Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F17%3A00479186" target="_blank" >RIV/67985807:_____/17:00479186 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21730/17:00320103 RIV/00216208:11130/17:10373472 RIV/00064203:_____/17:10373472

Result on the web

<a href="http://dx.doi.org/10.1016/j.diabres.2017.10.002" target="_blank" >http://dx.doi.org/10.1016/j.diabres.2017.10.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diabres.2017.10.002" target="_blank" >10.1016/j.diabres.2017.10.002</a>

Result language

angličtina

Original language name

Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Original language description

Aims: Cardiac autonomic neuropathy(CAN) is a frequent and severe complication of type 1 diabetes mellitus(T1DM). CAN diagnosis is associated with increased cardiovascular morbidity and mortality, often due to progressive atherosclerosis. Carotid intima media thickness(CIMT) is a surrogate marker of the atherosclerosis. The aim of our study was to evaluate the relationship between CIMT and CAN in T1DM patients. Methods: Total of 49 T1DM patients and 45 healthy controls were examined for CAN presence and CIMT. CAN was diagnosed based on the results of Ewing test battery and spectral analysis of heart rate variability. CIMT was measured by two-dimensional ultrasound. Biochemical, anthropometric and anamnestic risk markers of atherosclerosis were evaluated. We used logistic types of generalized additive models(GAM) for statistical analysis. Results: CAN was detected in 22 out of 49 T1DM patients(45%). All 45 healthy controls had normal cardiovascular autonomic tests results. CIMT was significantly positively associated with T1DM diagnosis(p=0.0251), CAN diagnosis(p=0.007), age(p<0.0001), BMI(p=0.0435) and systolic blood pressure(p=0.0098). CAN effect on CIMT interacted with the effect of T1DM. The combination of both factors significantly increased CIMT more than the sum of the individual T1DM and CAN status. Conclusions: CAN is significantly associated with higher CIMT in T1DM patients. CAN may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10103 - Statistics and probability

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes Research and Clinical Practice

ISSN

0168-8227

e-ISSN

—

Volume of the periodical

134

Issue of the periodical within the volume

December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

139-144

UT code for WoS article

000417318700016

EID of the result in the Scopus database

2-s2.0-85032588909