Interpoint distance tests for high-dimensional comparison studies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F20%3A00508148" target="_blank" >RIV/67985807:_____/20:00508148 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/02664763.2019.1649374" target="_blank" >http://dx.doi.org/10.1080/02664763.2019.1649374</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/02664763.2019.1649374" target="_blank" >10.1080/02664763.2019.1649374</a>

Result language
angličtina
Original language name
Interpoint distance tests for high-dimensional comparison studies
Original language description
Modern data collection techniques allow to analyze a very large number of endpoints. In biomedical research, for example, expressions of thousands of genes are commonly measured only on a small number of subjects. In these situations, traditional methods for comparison studies are not applicable. Moreover, the assumption of normal distribution is often questionable for high-dimensional data, and some variables may be at the same time highly correlated with others. Hypothesis tests based on interpoint distances are very appealing for studies involving the comparison of means, because they do not assume data to come from normally distributed populations and comprise tests that are distribution free, unbiased, consistent, and computationally feasible, even if the number of endpoints is much larger than the number of subjects. New tests based on interpoint distances are proposed for multivariate studies involving simultaneous comparison of means and variability, or the whole distribution shapes. The tests are shown to perform well in terms of power, when the endpoints have complex dependence relations, such as in genomic and metabolomic studies. A practical application to a genetic cardiovascular case-control study is discussed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10103 - Statistics and probability

Project
<a href="/en/project/GA19-05704S" target="_blank" >GA19-05704S: FoNeCo: Analytical Foundations of Neurocomputing</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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