Long-term outcome of Simpson IV meningioma resection: Would it improve with adjuvant SRS?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F21%3A00552206" target="_blank" >RIV/67985807:_____/21:00552206 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/21:00001067 RIV/00216208:11110/21:10429200
Result on the web
<a href="http://dx.doi.org/10.1016/j.clineuro.2021.106766" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2021.106766</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clineuro.2021.106766" target="_blank" >10.1016/j.clineuro.2021.106766</a>
Alternative languages
Result language
angličtina
Original language name
Long-term outcome of Simpson IV meningioma resection: Would it improve with adjuvant SRS?
Original language description
Objective: Subtotal meningioma resection (STR) is often performed to minimize surgical morbidity. Nevertheless, only a few studies have reported on patient outcome after STR. We studied the long-term outcome of SIV (Simpson grade IV) resection and identified predictive factors of overall survival (OS), progression-free survival (PFS) and time to progression (TTP). Methods: A retrospective analysis was performed on 68 patients who underwent SIV resection of meningioma (grade I) from 2004 to 2010. Data were collected from clinical, surgical and pathology records and radiological imaging. Long-term outcomes were evaluated at least 10 years after surgery. Results: Permanent morbidity was 11.8%, 30-day mortality 2.9% and progression rate 50.0% for a median followup duration of 126.6 months. Median TTP was 86.2 months. Adjuvant SRS was the only significant factor associated with longer PFS (p = 0.0052) and TTP (p = 0.0079). Higher age (p = 0.0022), KPS (p = 0.0182), postoperative ECOG score (p = 0.0182) were reliable predictors of shortened OS and aSRS (p = 0.0445) was reliable predictor of longer OS. Conclusion: STR in intracranial meningioma is still viable and often the only treatment option available in high risk patients or high-risk tumors. Although surgical morbidity and mortality are high, the OS rate was 85.3% at 5 years and 79.4% at 10 years. Because of the considerable progression rate and rather a long term OS the adjuvant SRS should be considered following SIV resection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NV19-04-00272" target="_blank" >NV19-04-00272: Relationship of meningioma origo to arachnoid membranes, extent of resection and surgical risks</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurology and Neurosurgery
ISSN
0303-8467
e-ISSN
1872-6968
Volume of the periodical
207
Issue of the periodical within the volume
August 2021
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
106766
UT code for WoS article
000715564200007
EID of the result in the Scopus database
2-s2.0-85108313746