The effect of immune correlates on the precision of vaccine efficacy evaluation: demographic subgroups

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F23%3A00576946" target="_blank" >RIV/67985807:_____/23:00576946 - isvavai.cz</a>
Result on the web
<a href="https://iscb.international/wp-content/uploads/2023/08/Book-of-Abstract-ISCB44_25-AGO-2.pdf" target="_blank" >https://iscb.international/wp-content/uploads/2023/08/Book-of-Abstract-ISCB44_25-AGO-2.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The effect of immune correlates on the precision of vaccine efficacy evaluation: demographic subgroups
Original language description
ZÁKLADNÍ ÚDAJE: ISCB44: 44th Annual Conference of the International Society for Clinical Biostatistics: Final Programme & Abstract Book. Milano: ISCB, 2023. s. 310-310. [ISCB 2023: Annual Conference of the International Society for Clinical Biostatistics /44./. 27.08.2023-31.08.2023, Milano]. ABSTRAKT: Clinical trials assessing vaccine efficacy typically provide data on binary and time-to-event clinical endpoints along with subjectspecific characteristics such as immune response to vaccination (immunogenicity) and demographics. Immunogenicity measurements often represent an established or a putative correlate of protection. Simulations have previously revealed that the understanding of efficacy in demographic subgroups can be substantially improved by quantifying the relationship betweenimmunogenicity and probability of disease (or of another binary clinical endpoint) and integrating that relationship with observed immunogenicity data to obtain relatively precise estimates of efficacy in subgroups of interest.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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