Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F24%3A00586406" target="_blank" >RIV/67985807:_____/24:00586406 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.simpa.2024.100667" target="_blank" >https://doi.org/10.1016/j.simpa.2024.100667</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.simpa.2024.100667" target="_blank" >10.1016/j.simpa.2024.100667</a>
Alternative languages
Result language
angličtina
Original language name
Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep
Original language description
Understanding the function of sleep and its associated neural rhythms is an important goal in neuroscience. While many theoretical models of neural dynamics during sleep exist, few include the effects of neuromodulators on sleep oscillations and describe transitions between sleep and wake states or different sleep stages. Here, we started with a C++-based thalamocortical network model that describes characteristic thalamic and cortical oscillations specific to sleep. This model, which includes a biophysically realistic description of intrinsic and synaptic channels, allows for testing the effects of different neuromodulators, intrinsic cell properties, and synaptic connectivity on neural dynamics during sleep. We present a complete reimplementation of this previously-published sleep model in the standardized NEURON/Python framework, making it more accessible to the wider scientific community.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/EH22_008%2F0004643" target="_blank" >EH22_008/0004643: Brain dynamics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Software Impacts
ISSN
2665-9638
e-ISSN
2665-9638
Volume of the periodical
21
Issue of the periodical within the volume
September 2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
100667
UT code for WoS article
001258888000001
EID of the result in the Scopus database
2-s2.0-85196149652