Incidence of congenital microcephaly in the Czech Republic: The effect of maternal age

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00637173" target="_blank" >RIV/67985807:_____/25:00637173 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10499244 RIV/00216208:11120/25:43928604 RIV/00064190:_____/25:10001389 RIV/75010330:_____/25:00014982 RIV/00064165:_____/25:10499244

Result on the web

<a href="https://doi.org/10.32725/jab.2025.009" target="_blank" >https://doi.org/10.32725/jab.2025.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32725/jab.2025.009" target="_blank" >10.32725/jab.2025.009</a>

Result language

angličtina

Original language name

Incidence of congenital microcephaly in the Czech Republic: The effect of maternal age

Original language description

OBJECTIVE: Congenital microcephaly is a diverse group of congenital anomalies characterized by a significantly reduced head circumference at birth. The incidence varies widely across regions. This study focuses on the incidence of microcephaly in the Czech Republic. METHODS: A retrospective analysis was conducted using data from the National Registry of Congenital Anomalies of the Czech Republic. All cases coded as microcephaly (Q02 code in the 10th revision of the International Classification of Diseases) between 2000 and 2020 were included. RESULTS: A total of 274 cases of congenital microcephaly were identified, with an incidence rate of 1.22 per 10,000 births. The sex ratio was significantly skewed toward females (0.63:0.37). Microcephaly was significantly more frequent among mothers aged less than 25 years (1.68 per 10,000) and over 35 years (1.51 per 10,000), compared to those aged 25–34 years (1.03 per 10,000). CONCLUSION: This research provides the most detailed population-based estimate of congenital microcephaly in the Czech Republic. The study reports a lower relative incidence compared to many other countries. The findings highlight significant associations with maternal age and a notable female predominance, warranting further investigation into genetic and biological mechanisms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

1214-0287

Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

91-95

UT code for WoS article

001514123100001

EID of the result in the Scopus database

2-s2.0-105009734115