Microstate in rats' EEG: a proof of concept study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00643765" target="_blank" >RIV/67985807:_____/25:00643765 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/25:43921615 RIV/68407700:21230/25:00386549 RIV/68407700:21460/25:00386549 RIV/00216208:11120/25:43929081

Result on the web

<a href="https://doi.org/10.1038/s41398-025-03702-y" target="_blank" >https://doi.org/10.1038/s41398-025-03702-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41398-025-03702-y" target="_blank" >10.1038/s41398-025-03702-y</a>

Result language

angličtina

Original language name

Microstate in rats' EEG: a proof of concept study

Original language description

The electroencephalogram (EEG) reflecting brain activity may be characterised through brief periods of stable neural activity patterns that recur over time and are referred to as microstates. Microstates are related to a range of cognitive processes, and their analysis has become an increasingly popular tool for studying human brain function. While microstates have been extensively studied in humans, their presence and characteristics in animal models have yet to be as thoroughly investigated. This study aims to address this gap by detecting and characterising microstates in EEGs of rats collected using a superficial electrode system corresponding to homological areas of the human 10–20 system. Specifically, we demonstrate the presence of microstates in rats’ EEGs, i.e., those that may be captured by the same metrics as in humans. We identified five microstate EEG maps in rats, explaining 71% of the variance in our dataset (N = 30). The explained variance, mean temporal coverage values (0.2), and average duration (0.26 s) are comparable to the human-derived EEG microstates. Via a source localisation technique, the cingulate cortex, precuneus, and insula were found to be associated with the microstates’ temporal dynamics. Among the microstates that showed a broadband character, we also found those that showed an association with the theta and alpha bands. These findings have important implications for the use of microstates as a preclinical tool for investigating brain functions, detecting new biomarkers of brain diseases, and translating this knowledge to humans.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Translational Psychiatry

ISSN

2158-3188

e-ISSN

2158-3188

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

494

UT code for WoS article

001621098500001

EID of the result in the Scopus database

2-s2.0-105022654359