Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010177" target="_blank" >RIV/67985823:_____/01:20010177 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.
Original language description
The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system (RAS) in hearts of normotensive and hypertensive rats. Two genetically hypertensive rat strains - spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic rats (HTG) - were compared with Wistar-Kyoto (WKY) and Lewis (LEW) normotensive controls. In addition, developmental changes in gene expression of individual components of cardiac RAS were studied in 20-day-old fetuses, 2-day-old newborns and 3-month-old HTG and LEW rats. Angiotensinogen gene expression did not differ either among adult normotensive and hypertensive strains, or during development. The renin gene expression was significantly increased in hypertensiveheart when compared to normotensive one. There was also an age-dependent increase of ACE gene expression in both HTG and LEW rats, which was delayed in HTG hearts. Results suggest that overexpression of the cardiac renin gene in hyperten
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA7011805" target="_blank" >IAA7011805: Oxygen free radicals and nitric oxide in the pathogenesis of age-dependent experimental hypertension: the attenuation of vasodilator mechanisms ...</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
35-42
UT code for WoS article
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EID of the result in the Scopus database
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