Ultraviolet light-irradiated collagen III modulates expression of cytoskeletal and surface adhesion molecules in rat aortic smooth muscle cells in vitro.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020002" target="_blank" >RIV/67985823:_____/02:20020002 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/02:00000237 RIV/00216208:11130/02:00006817
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ultraviolet light-irradiated collagen III modulates expression of cytoskeletal and surface adhesion molecules in rat aortic smooth muscle cells in vitro.
Original language description
Collagen III was irradiated with ultraviolet light, which resulted in its fragmentation and oxidation. Vascular smooth muscle cells (VSMC), seeded on the modified collagen, exhibited lower concentration of some adhesion-mediating and cytoskeletal molecules (beta-1 integrins, vinculin, talin, vimentin). These molecules were also less organized into focal adhesion plaques or cytoskeletal fibres. At the same time, the VSMC proliferated more rapidly and expressed more immunoglobulin adhesion molecules ICAM-1 and VCAM-1. These results suggest that alterations of vascular extracellular matrix can lead to tje escape of VSMC from the matrix-mediated growth control and to the attraction of cells of the immune system.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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