Report on the first patient group of the phase I BNCT trial at the LVR-15 reactor.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020083" target="_blank" >RIV/67985823:_____/02:20020083 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Report on the first patient group of the phase I BNCT trial at the LVR-15 reactor.
Original language description
Clinical trials of Neutron Capture Therapy were initiated in some European countries including Czech Republic [1]. An epithermal neutron beam was constructed at the LVR-15 nuclear reactor at Řez near Prague. The phase I study of the Protocol approved byState Institute for Drug Control and State Office for Nuclear Safety of the Czech Republic has been used to define the limiting toxicity of the BNCT procedure. The group of 9 patients received BSH and underwent surgery, 5 patients were treated using BSHat the epithermal neutron facility of LVR-15 reactor in NRI Rez. No clinical deterioration of patients or laboratory data were observed during and after infusion of BSH, including normal kidney and liver functions. Immediately after the irradiation, in two patients there appeared nausea, vomiting or a grade II skin reaction in the irradiated area appeared within 3 weeks after the irradiation. One patient died in the first week after irradiation due to pulmonary embolism. In the remaining
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
BG - Nuclear, atomic and molecular physics, accelerators
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Research and development in neutron capture therapy. Proceedings of the 10th International Congress on Neutron Capture Therapy.
ISBN
88-323-2909-3
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
1107-1112
Publisher name
Monduzzi Editore
Place of publication
Bologna
Event location
Essen [DE]
Event date
Sep 8, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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