Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020111" target="_blank" >RIV/67985823:_____/02:20020111 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/02:00000064 RIV/00216208:11130/02:00000059
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage.
Original language description
The aim of the study was to determine at what dosage and after how long impairment of hippocampal function occurs, following radiosurgery of the rat hippocampus using the Leksell gamma knife, and to study the associated structural changes. The Long-Evansrats were irradiated with the doses of 25, 50, 75, 100 and 150 Gy to a maximum, using 4 isocenters of 4mm collimator to cover the hippocampus bilaterally. The impairment of hippocampal function, which is associated with a loss of memory, was measured bytesting the impairment of the rats' orientation in a Morris water maze. Changes in the irradiated tissue of the rats were measured by means of MR imaging using a Bruker 4.7/20 experimental spectrometer. The data obtained by these measurements were compared with histological changes. A significantly higher frequency of edema, necrosis and behavioral changes was observed for doses higher than 50 Gy. No edema, necrosis and behavioral changes were observed for doses of 25 Gy. The study show
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BG - Nuclear, atomic and molecular physics, accelerators
OECD FORD branch
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Project
<a href="/en/project/NF5161" target="_blank" >NF5161: Radiosurgical lesion of the rat hippocampus using the Leksell gamma knife: relation between radiation dose and functional and structural damage.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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