The effects of hydrocortisone on rat heart muscarinic and adrenergic alpha(1), beta(1) and beta(2) receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030157" target="_blank" >RIV/67985823:_____/03:20030157 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The effects of hydrocortisone on rat heart muscarinic and adrenergic alpha(1), beta(1) and beta(2) receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling.
Original language description
We injected rats with hydrocortisone for 1-12 days and measured the densities of cardiac muscarinic receptors, adrenoceptors and propranolol-resistant biding sites. The density of cardiac muscarinic receptors increased (in both the atria and the ventricles). The density of beta1-adrenoceptors increased in the atria and was little changed in the vetricles. The density of beta2-adrenoceptors increased in both the atria and the ventricles. The number of alpha1-adrenoceptors decreased, and transient increase in the atria and no changes in the ventricles followed it. The density of propranolol-resistant binding sites first increased and then diminished in the atria and did not change in the ventricles. In can indicate that changes in receptor densities could be one from the mechanisms that participate in maitaining stable functional output.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Naunyn-Schmiedebergs Archives of Pharmacology
ISSN
0028-1298
e-ISSN
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Volume of the periodical
368
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
366-376
UT code for WoS article
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EID of the result in the Scopus database
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