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Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: Regional and ontogenetic studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F07%3A00096402" target="_blank" >RIV/67985823:_____/07:00096402 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of LiCl/pilocarpine-induced status epilepticus on rat brain mu and benzodiazepine receptor binding: Regional and ontogenetic studies

  • Original language description

    Using in vitro autoradiography, benzodiazepine (BDZ) and ÎĽ opioid receptor binding was evaluated 1 week and 3 months after SE in 27 brain structures involved in seizure generation and spread (amygdala, hippocampus, basal ganglia and thalamic nuclei). The pattern of receptor binding changes was related to the age at SE, interval after SE and to brain structures. Whereas in P12 BDZ binding was increased 1week after SE, significant decrease occurred in both P25 and adult rats 3 mo after SE. ÎĽ opioid receptors were less significantly affected but clear tendency to decrease binding occurred in adult rats in various cortical, amygdala and thalamic regions early after SE

  • Czech name

    Důsledky LiCl/pilokarpinového epileptického statu na benzodiazepinovou a ? opiodní receptorovou vazbu v mozku potkana. Strukturální a ontogenetická studie

  • Czech description

    S použitím in vitro autoradiografie jsme zjistili, že změny benzodiazepinové (BZD) i ? opioidové vazby po epileptickém statu (SE) jsou závislé na věku, měřené struktuře mozku a intervalu po SE. Zatímco u P12 potkanů dochází k vzestupu BDZ vazby 1 týden po SE, u dospělých a P25 zvířat je 3 měsíce po SE vazba signifikantně snížena. ? opioidní receptory jsou ovlivněny méně významně, ale u dospělých zvířat byla patrná tendence ke snížení vazby v různých korových, amygdalárních a talamických oblastech

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Brain Research

  • ISSN

    0006-8993

  • e-ISSN

  • Volume of the periodical

    1181

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    14

  • Pages from-to

    104-117

  • UT code for WoS article

  • EID of the result in the Scopus database