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Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related

Result description

The effect of thiazide-like diuretic-indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) was studied in order to assess the involvement of nitric oxide in this process. Indapamide prevented myocardial fibrosis development in SHR, but without affecting collagen type I to type III ratio. Indapamide did not affect NOS activity as well as eNOS and iNOS protein expressions in the left ventricles. Thus indapamide-induced prevention of myocardial fibrosis isnot mediated by nitric oxide-related mechanism

Keywords

indapamidemyocardial fibrosisgenetic hypertension

The result's identifiers

Alternative languages

  • Result language

    angličtina

  • Original language name

    Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related

  • Original language description

    The effect of thiazide-like diuretic-indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) was studied in order to assess the involvement of nitric oxide in this process. Indapamide prevented myocardial fibrosis development in SHR, but without affecting collagen type I to type III ratio. Indapamide did not affect NOS activity as well as eNOS and iNOS protein expressions in the left ventricles. Thus indapamide-induced prevention of myocardial fibrosis isnot mediated by nitric oxide-related mechanism

  • Czech name

  • Czech description

Classification

  • Type

    Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    56

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    4

  • Pages from-to

  • UT code for WoS article

    252358700020

  • EID of the result in the Scopus database