Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related
Result description
The effect of thiazide-like diuretic-indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) was studied in order to assess the involvement of nitric oxide in this process. Indapamide prevented myocardial fibrosis development in SHR, but without affecting collagen type I to type III ratio. Indapamide did not affect NOS activity as well as eNOS and iNOS protein expressions in the left ventricles. Thus indapamide-induced prevention of myocardial fibrosis isnot mediated by nitric oxide-related mechanism
Keywords
The result's identifiers
Result code in IS VaVaI
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related
Original language description
The effect of thiazide-like diuretic-indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) was studied in order to assess the involvement of nitric oxide in this process. Indapamide prevented myocardial fibrosis development in SHR, but without affecting collagen type I to type III ratio. Indapamide did not affect NOS activity as well as eNOS and iNOS protein expressions in the left ventricles. Thus indapamide-induced prevention of myocardial fibrosis isnot mediated by nitric oxide-related mechanism
Czech name
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Czech description
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Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
56
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
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UT code for WoS article
252358700020
EID of the result in the Scopus database
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Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
ED - Physiology
Year of implementation
2007