DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F09%3A00334067" target="_blank" >RIV/67985823:_____/09:00334067 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/09:00334067

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism

Original language description

In the body the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Thyroid hormone receptors, activated in response to thyroid hormone (T3), are known to modulate the level of serum cholesterol via complex regulatory pathways. By screening for T3-regulated genes we identified Disp3, a sterol-sensing protein that is related to the Dispatched family of proteins. Using the model of hyperthyroidism in vivo we observed modulation of the Disp3 expression. DISP3 localizes within the endoplasmic reticulum and was further found to co-localize with cholesterol. Ectopic expression of DISP3 resulted in elevated cholesterol levels combined with an altered cholesterol distribution. Taken together, we propose that DISP3 represents a new molecular link between thyroid hormone and cholesterol metabolism in the brain.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/IAA500520705" target="_blank" >IAA500520705: Characterization of the new member of sterol-sensing-domain protein family and its role in lipid metabolism</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Endocrinology

ISSN

0888-8809

e-ISSN

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Volume of the periodical

23

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000264707000010

EID of the result in the Scopus database

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