Mitochondrial K-ATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F09%3A00337058" target="_blank" >RIV/67985823:_____/09:00337058 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Mitochondrial K-ATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms

Original language description

In isolated perfused rat hearts, bracketing of diazoxide (K-ATP opener) with wortmannin (PI3K inhibitor) blunted its infarct size-limiting effect but not the protection against ischemic arrhythmias. It appears, that PI3K/Akt pathway play a positive roleof the K-ATP opener against lethal myocardial injury, but it is not involved in suppression of ischemia-induced arrhythmias

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Canadian Journal of Physiology and Pharmacology

ISSN

0008-4212

e-ISSN

—

Volume of the periodical

87

Issue of the periodical within the volume

12

Country of publishing house

CA - CANADA

Number of pages

8

Pages from-to

—

UT code for WoS article

273419000010

EID of the result in the Scopus database

—